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View Full Version : METHOTREXATE NOT WORKING


1WeekAtATime
11-10-2007, 01:12 AM
Hey all. I have been taking Trexall for my PA, and it's making things worse, so I'm being switched to a new medicine. I haven't had the appointment to discuss options yet, but I know they want me to use Enbrel, Remicade, or Humira.

Over the summer, I used Enbrel, but had some nasty injection site reactions. The dermatologist said that if I take it and that happens again, I have to keep injecting until they've cleared. The only problem is that it took weeks to clear, and I am NOT injecting into swollen flesh.

My other options are Remicade and Humira. I'd LOVE to have Remicade infusions, but I hear the medicine stops working after a period of time for a lot of people. Otherwise, I don't care about the rat proteins or whatever is in there- I don't want to stick myself with a needle forever.

So then there's Humira, which is probably what the rheumy will want me to take. There's an injector pen now which is awesome, but I had to do Enbrel twice a week and also inject anti-coagulant into my stomach the entire summer, and I'm sick of sticking myself all the time. Also, I'm worried that if I have to do a double-dose, after 2 years I would be required to half the dose and then not feel as good, which is what someone on Enbrel had to do. If I'm going to go through the self-mutilation of injection all the time, I want it to work!

What are your thoughts/experiences with these medicines? Do all people on Remicade eventually reach a point in which it does not work anymore??

Malibu 2
11-11-2007, 07:17 AM
Hey all. I have been taking Trexall for my PA, and it's making things worse, so I'm being switched to a new medicine. I haven't had the appointment to discuss options yet, but I know they want me to use Enbrel, Remicade, or Humira.

Over the summer, I used Enbrel, but had some nasty injection site reactions. The dermatologist said that if I take it and that happens again, I have to keep injecting until they've cleared. The only problem is that it took weeks to clear, and I am NOT injecting into swollen flesh.

My other options are Remicade and Humira. I'd LOVE to have Remicade infusions, but I hear the medicine stops working after a period of time for a lot of people. Otherwise, I don't care about the rat proteins or whatever is in there- I don't want to stick myself with a needle forever.

So then there's Humira, which is probably what the rheumy will want me to take. There's an injector pen now which is awesome, but I had to do Enbrel twice a week and also inject anti-coagulant into my stomach the entire summer, and I'm sick of sticking myself all the time. Also, I'm worried that if I have to do a double-dose, after 2 years I would be required to half the dose and then not feel as good, which is what someone on Enbrel had to do. If I'm going to go through the self-mutilation of injection all the time, I want it to work!

What are your thoughts/experiences with these medicines? Do all people on Remicade eventually reach a point in which it does not work anymore??

Good Morning 1WAAT

I am not on any injection meds yet (only MXT) but I am going on the Remicade first of the year, per my Rheumy direction. He stated because I'm still young he wants to be aggressive and stop anymore damage to my joints.

First off, are you seeing a Derm or a Rheumy?? Do you have PA or just P? I have not heard anything about the Remicade not working after awhile, but on the other hand I have a friend who's been on the Enbrel for years and now hr Dr. wants to put her on Humira. So I think your body can become resistant to any drug over time.

I personally would seek a Rhuemy if you don't have one and I would do the Remicade if it's provided to you and if your Dr approves it.
Good Luck and keep us posted
Malibu

BarbO
11-12-2007, 08:29 AM
I have PA without the psoriasis; my rheumy put me on methotrexate 10 weeks ago (when I was diagnosed). This morning, due to side effects and still having a fair bit of inflammation he switched me to Arava (actually the generic leflunomide). Supposedly it has less side effects, anyways it might be another option for you. I like the fact that I don't have to inject it and it isn't supposed to upset your stomach! Hopefully it will help my hands, I teach 5th grade and really need to be able to write and grade papers without pain pills.