Moderate to severe psoriasis: systemic medications - cyclosporine

Cyclosporine is an immunosuppressive drug that was first used to help prevent rejection in organ transplant patients. In 1997, the Food and Drug Administration (FDA) approved Neoral for adults with severe psoriasis.

Cyclosporine suppresses the immune system and slows down the growth of certain immune cells.

Do not take cyclosporine if you have:

• A compromised immune system
• Abnormal kidney function
• High blood pressure
• Cancer, or a history of cancer (other than basal or squamous cell skin cancers)
• Severe gout.

Additionally, do not take cyclosporine if you are:

• Pregnant or breastfeeding
• Undergoing radiation treatment.

Individuals previously treated with PUVA, methotrexate or other immunosuppressive agents, UVB, coal tar, or radiation therapy are at an increased risk of developing skin cancer when taking cyclosporine. Additional risks with cyclosporine include kidney damage. This increases with length of time and amount of cyclosporine taken. Your doctor will monitor your kidney function before and during treatment. Patients can also develop hypertension on this medication so frequent blood pressure checks are important.