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CBD for Psoriasis and PsA

What to know about the potential benefits of CBD in treating psoriatic disease.

In recent years, consumer interest in the potential benefits of cannabidiol (CBD) has grown. [1] In response, a wide range of over-the-counter (OTC) products containing CBD have become available, from capsules and oils to moisturizers and food supplements. [2] [3] However, the extent to which CBD products are safe or effective is unclear. [4] [5] [6]

CBD is one of more than 80 chemical compounds found in a plant genus called Cannabis. [7] It is one of the two better-known compounds. CBD is nonintoxicating compared with tetrahydrocannabinol (THC), which produces the “high” typically associated with cannabis. These compounds occur naturally and at varying potencies in cannabis plants, and they can be extracted and used in product development.

“Most of what we understand about CBD and other cannabinoids comes from cell-line data, some animal studies, but very few human studies,” according to Adam Friedman, M.D., Professor and Chair of Dermatology in the Department of Dermatology at George Washington School of Medicine and Health Sciences in Washington, D.C.

For many years, regulations have made it difficult to study any part of the plant. [8] [9] More confusing is the conflict between state and federal regulations, which has led to a growing number of available skincare products that have not been tested for safety or efficacy. [4] [5] [6]

However, “there’s certainly enough mechanistic data to argue that [CBD] makes sense for psoriasis,” Dr. Friedman says. In studies, CBD has demonstrated its potential for use in several skin-related disorders, including psoriatic disease. [10] [11]  

Psoriatic disease is a chronic, immune-mediated systemic condition that includes psoriasis and psoriatic arthritis. It results from abnormal immune activity that promotes inflammation, which can affect the skin or the joints. Visibly, it is characterized in part by plaques and scales on the skin that result from the overactive immune system and rapid reproduction of skin cells. But because it is a systemic condition, there may be inflammation happening beneath the skin. If this inflammation affects the joints, it may result in swelling, stiffness and joint pain. [12]

“CBD has the ability to bind to receptors in the body that are part of the human cannabinoid system, called endocannabinoids, that can influence pain, itch and mechanisms of inflammation,” Dr. Friedman says. “We know that when CBD binds to the CB2 [cannabinoid receptor type 2] as well as other receptors, it can be involved in not just anti-inflammatory activity, but it can facilitate an array of activities that resolve inflammation. It can stimulate the secretion and recruitment of cells that are important for removing debris and allowing for proper skin maturation and healing.”

While the relationship may be complex, studies that point to practical applications are emerging. A 2016 study showed that an endocannabinoid called anandamide was able to prevent the production of key inflammation signals that are known to initiate and perpetuate psoriasis in skin and immune cells. [13]

Outcomes from a 2019 study investigating a topical CBD ointment applied to skin lesions twice daily for two months indicated that the CBD ointment improved skin hydration and elasticity as well as quality-of-life measures that were assessed with the Psoriasis Area Severity Index. [14]

A more recent study published at the end of 2020 examined a shampoo containing CBD that was effective at reducing the severity of scalp inflammation, itching and burning in patients with scalp psoriasis or seborrheic dermatitis. [15]

Other studies point to a CBD benefit for quality-of-life measures related to psoriasis. There is evidence that CBD may improve sleep and reduce depression and anxiety, but more research is needed to clarify this connection. [16]

A CBD-derived product currently on the market, Epidiolex, is approved by the Food and Drug Administration (FDA) for the treatment of seizures associated with certain epilepsy syndromes and tuberous sclerosis. [17] “This means that we have a lot of useful safety information when it comes to systemic administration,” Dr. Friedman says. “However, we have no data specific to psoriasis.”

When it comes to OTC products, oral CBD products are technically not legal because they are not FDA-approved drugs or supplements, Dr. Friedman adds. But discrepancies between federal and state laws have resulted in poor regulation and oversight and continued sales. This also has led to product labels that do not accurately reflect the actual CBD content, Dr. Friedman points out.

Data reported in the Journal of the American Medical Association showed that CBD products varied widely in their concentrations. [18] Among 84 CBD-containing products sold online in 2016, nearly half (42.85%) were under-labeled, meaning the actual amount of CBD in the product was more than 10% above the labeled concentration. About one-quarter (26.19%) of the products contained at least 10% less CBD than the label noted.

A smaller, more recent study found that only 12% of products were within 20% of what the label noted. Sixty percent of products contained CBD concentrations well below the labeled value, and 8% exceeded the labeled value by 50%. [19] Additionally, some studies have shown that OTC formulations may carry impurities that can result in allergic contact dermatitis. [20]

This inconsistency suggests a need for federal and state regulatory agencies to take steps to ensure label accuracy for these consumer products. Right now, you don’t always know what you’re getting when you’re buying OTC CBD products, Dr. Friedman says.

“Now, let's be honest: If there's nothing in there that's harmful, does simply putting a cream on psoriatic skin have benefit? Yes,” he says. “Simply moisturizing the skin, softening that really thick retained stratum corneum [outer layer of the skin], could have some benefit both from a symptom perspective, but even maybe some mild anti-inflammatory activity.”

However, CBD often is combined with other ingredients like camphor, which can relieve pain, irritation or itching, or salicylic acid, which acts to break down thick, scaly skin. So it's hard to know what's actually doing the work, Dr. Friedman says.

Topicals designed to effectively deliver CBD into the skin need to be developed with specific factors in mind, says Dr. Friedman. Cannabinoids are very lipophilic, meaning they like fatty environments. To constitute CBD in an effective topical formulation, the topical has to be greasy or oily – hence, CBD oil. Also, the top layer of the skin is full of fat. When you put a topical ingredient that likes a fatty environment on the skin, it has a hard time penetrating and will remain in that top layer. This is true of cannabinoids. Now, consider psoriasis, in which you have a very thick top layer, and that makes it harder for the cannabinoid to penetrate the skin, Dr. Friedman explains.

Before individuals apply something to their skin, they should do due diligence and check the quality assurance practices of the company, Dr. Friedman suggests. Visit the website or call the company. Look for companies that are reputable and that will provide details on their approach to ensure a pure product.

“While we can't answer the question ‘Which product should I get?’ based on any clinical evidence at this time, what we can say is: Chances are it won't hurt; maybe it will help,” he says.

Of course, before applying or trying any CBD product or treatment options, individuals should consult a health care provider.

Because psoriasis is a systemic disease associated with many significant comorbidities, cannabis-containing products should be considered an adjunct or complementary approach to treatment. CBD may be used with treatments like topical steroids, biologics and molecule inhibitors, not in place of them, Dr. Friedman warns.

“In an ideal world, if CBD could be delivered correctly, in the right amount, at the right frequency, it could have a lot of potential for many inflammatory skin diseases like psoriasis,” he says.

Efforts to address the many remaining questions related to CBD use are underway by members of the National Psoriasis Foundation Medical Board, who will review evidence and put forth guidance for the psoriatic disease community.

 

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Article References

References

1. Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling accuracy of cannabidiol extracts sold online. JAMA. 2017;318(17):1708-1709.

2. Jhawar N, Schoenberg E, Wang JV, Saedi N. The growing trend of cannabidiol in skincare products. Clin Dermatol. 2019;37(3):279-281.

3. Chesney E, McGuire P, Freeman TP, Strang J, Englund A.  Lack of evidence for the effectiveness or safety of over-the-counter cannabidiol products. Ther Adv Psychopharmacol. 2020. doi: 10:204512532095499.

4. Jhawar N, Schoenberg E, Wang JV, Saedi N. The growing trend of cannabidiol in skincare products. Clin Dermatol. 2019;37(3):279-281.

5. Hashim PW, Cohen JL, Pompei DT, Goldenberg G. Topical cannabinoids in dermatology. Cutis. 2017;100(1):50-52.

6. Eagleston LRM, Yazd NKK, Patel RR, Flaten HK, Dunnick CA, Dellavalle RP. Cannabinoids in dermatology: a scoping review. Dermatology Online J. 2018;24(6):1-17.

7. FDA. FDA and cannabis: research and drug approval process. Updated Oct 2020. https://www.fda.gov/news-events/public-health-focus/fda-and-cannabis-research-and-drug-approval-process.

8. Baumann LS. A primer on cannabis for cosmeceuticals: the endocannabinoid system. MDedge. Apr 20, 2019.

9. Hudak J. The Farm Bill, hemp legalization and the status of CBD: an explainer. Brookings. Dec 14, 2018.

10. Baswan SM, Klosner AE, Glynn K, et al. Therapeutic potential of cannabidiol (CBD) for skin health and disorders. Clin Cosmet Investig Dermatol. 2020;13:927-942.

11. Sheriff T, Lin MJ, Dubin D, Khorasani H. The potential role of cannabinoids in dermatology. J Dermatolog Treat. 2020;31(8):839-845.

12. National Psoriasis Foundation. About psoriasis. Updated Jan 14, 2021.

13. Chiurchiù V, Rapino C, Talamonti E, et al. Anandamide suppresses proinflammatory t cell responses in vitro through type-1 cannabinoid receptor–mediated mTOR inhibition in human keratinocytes. J Immunol. 2016;197(9):3545-3553.

14. Palmieri B, Laurino B, Vadalà M. A therapeutic effect of CBD-enriched ointment in inflammatory skin diseases and cutaneous scars. Clin Ter. 2019;(2):93-99.

15. Vincenzi C, Tosti A. Efficacy and tolerability of a shampoo containing broad-spectrum cannabidiol in the treatment of scalp inflammation in patients with mild to moderate scalp psoriasis or seborrheic dermatitis. Skin Appendage Disord. 2020;6(6):355-361.

16. Cather J. CBD in the holistic practice of dermatology. Pract Dermatol. July 2020;41-42,56.

17. Epidiolex (cannabidiol). Carlsbad, CA: Genentech Biosciences. Revised Apr 2020. https://www.epidiolex.com/sites/default/files/pdfs/1120/EPX-03645-1120_EPIDIOLEX_(cannabidiol)_USPI.pdf.

18. Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Labeling accuracy of cannabidiol extracts sold online. JAMA. 2017;318(17):1708.

19. Gurley BJ, Murphy TP, Gul W, Walker LA, ElSohly M. Content versus label claims in cannabidiol (CBD)-containing products obtained from commercial outlets in the state of Mississippi. J Diet Suppl. 2020;17(5):599-607.

20. Rianprakaisang T, Gerona R, Hendrickson RG. Commercial cannabidiol oil contaminated with the synthetic cannabinoid AB-FUBINACA given to a pediatric patient. Clin Toxicol. 2020;58(3):215-216.

Author

Heather Onorati

Title

Freelance writer

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