FDA approves Bryhali Lotion for psoriasis

On Nov. 6, 2018, the U.S. Food and Drug Administration (FDA) approved the use of the topical corticosteroid Bryhali (halobetasol propionate) Lotion, 0.01 percent, for the treatment of moderate-to-severe psoriasis.

The prescription-only topical, manufactured by Ortho Dermatologics, can be used once a day for eight weeks.

Ortho Dermatologics published the efficacy and safety data from two phase 3 studies on Bryhali Lotion in the current issue of The Journal of Drugs in Dermatology. According to the study, by week eight, 37 percent (study 1) and 38 percent (study 2) of patients using Bryhali Lotion had achieved treatment success, defined as a) at least a two-grade improvement from their baseline in an Investigator Global Assessment score and b) “clear” or “almost clear” skin. 

At four weeks post-treatment, the recurrence of psoriasis symptoms was not observed in patients using Bryhali Lotion. Patients also tolerated the topical well. Approximately one in five reported some adverse reactions, the most common being upper respiratory tract infection, skin irritation and high blood sugar.

“The therapeutic world of psoriasis has evolved to the point where 50 percent of our patients with moderate-to-severe psoriasis can be clear of disease for years,” says Jerry Bagel, M.D., Psoriasis Treatment Center of Central New Jersey, East Windsor, New Jersey, and NPF medical board member. 

Patient-centered outcomes

During a day-long Patient-Focused Drug Development meeting on psoriasis in 2016, the FDA heard directly from individuals living with psoriatic disease about their challenges in managing the symptoms of psoriasis. Thanks to NPF's advocacy efforts, more than 200 individuals impacted by psoriasis joined this meeting. Participants expressed a recurring theme: the need for new, effective and tolerable treatment options to improve their quality of life.

Since 1987, NPF has funded more than $19 million in research into psoriatic disease, helping to lay the groundwork for new drugs and, eventually, a cure. NPF also connects people with clinical trials so that more treatment options may be tested and ultimately approved.  

More resources for you

We know that treating psoriatic disease can be challenging. If you would like to learn more about treatment options, including Bryhali Lotion, contact our Patient Navigation Center. Our specially trained navigators offer free, personalized support to help you live your healthiest life with psoriatic disease.


Driving discovery, creating community

For more than 50 years, we’ve been driving efforts to cure psoriatic disease and improve the lives of those affected. But there’s still plenty to do! Learn how you can help our advocacy team shape the laws and policies that affect people with psoriasis and psoriatic arthritis – in your state and across the country. Help us raise funds to support research by joining Team NPF, where you can walk, run, cycle, play bingo or create your own fundraising event. If you or someone you love needs free, personalized support for living a healthier life with psoriatic disease, contact our Patient Navigation Center. And keep the National Psoriasis Foundation going strong by making a donation today. Together, we will find a cure.

Recent Advance Posts

Head shot Hillel Katzeff
Hillel Katzeff was extremely fast on land until PsA forced him to trade in his...
psoriasis, research, treatment, TNF
New therapies on the horizon target psoriasis and PsA in novel ways.
cartoon hands and hearts reaching for the stars
Yogi Berra said, “It ain’t over till it’s over.” You still have a few weeks...
telemedicine, phone, people
No matter how far the distance between you and your health care providers,...
winter flares, iceberg
Do you feel like the cold, dark weather triggers your psoriasis or psoriatic...
sea, insurance, marketplace
For patients with psoriatic disease who purchase health insurance through the...
insurance term graphic, pen, paper
Health insurance has a language all its own – and it sometimes gets a bit...
mom hugs kid
Open communication is key to empowering your child to understand his disease...
cartoon of scientists and patient against giant tablet
A New York researcher wants to gather every smart person he can to help build a...