FDA approves Skyrizi for plaque psoriasis

| Chris Paoli

Adults suffering from psoriatic disease have a new treatment option. On April 23, the U.S. Food and Drug Administration approved the use of Skyrizi (risankizumab), an IL-23 inhibitor that targets a key protein involved in inflammatory disease.

Skyrizi, manufactured by AbbVie pharmaceuticals, is for those with moderate-to-severe plaque psoriasis, and is specifically aimed at anyone who is a candidate for systemic therapy or phototherapy.

Patients in clinical trials for Skyrizi received 150 mg of risankizumab administered by two subcutaneous (under the skin) injections (75 mg/0.83 mL in each single-dose prefilled syringe) at the start of treatment, one month later and every 12 weeks thereafter for maintenance therapy.  

Speaking on the importance of drug options for patients, Steven R. Feldman, M.D., Ph.D., NPF medical board member, says that the growing list of new treatments has a large impact on patient lives. 

“No one treatment works for everyone,” says Feldman. 

Since 1987, NPF has invested more than $19 million in psoriatic disease research, which has directly contributed to the wave of newly approved treatment options like Skyrizi. NPF also helps connect patients with clinical trials so that more drugs may be tested and ultimately approved. 

Phase 3 clinical trials of Skyrizi for psoriatic arthritis are currently being conducted.

Once a treatment is approved, NPF offers a wealth of resources and works to ensure proper access for the best patient care. NPF also provides medical education to health care providers so they can stay up-to-date on the latest treatment options. 

Know your options 
To learn more about your treatment options, including information on Skyrizi, contact the Patient Navigation Center. NPF patient navigators offer free resources and personalized support to help you understand and access treatments.


Driving discovery, creating community

For more than 50 years, we’ve been driving efforts to cure psoriatic disease and improve the lives of those affected. But there’s still plenty to do! Learn how you can help our advocacy team shape the laws and policies that affect people with psoriasis and psoriatic arthritis – in your state and across the country. Help us raise funds to support research by joining Team NPF, where you can walk, run, cycle, play bingo or create your own fundraising event. If you or someone you love needs free, personalized support for living a healthier life with psoriatic disease, contact our Patient Navigation Center. And keep the National Psoriasis Foundation going strong by making a donation today. Together, we will find a cure.

Recent Advance Posts

NPF Early Career Research Grant recipient Holly Anderton chats about how she...
image of foam with the words "FDA approved"
Lexette, a topical corticosteroid foam, aims to reduce plaques.
FDA Approved Topical
The latest topical lotion aims to reduce plaque and clear your skin.
Pstamp Out Portland
Team NPF is putting the fun in fundraising with a series of Pstamp Out events...
Philip Mease in office in front of Seattle skyline
From barefoot doctor to world-renowned rheumatologist and researcher – meet our...
Anthony Getschman
NPF Early Career Research Grant recipient Anthony Getschman discusses his...
Clockwise from left, Brittany Duffy-Goche, Marc Boas, Pete Redding, Tami Seretti, Lisa Bayautet
How patients descended on our nation’s capitol for NPF’s annual fly-in.
headshot of Nsarg Shah
This chemical engineer approaches psoriatic arthritis from a whole new angle.
FDA Approval Skyrizi
The latest interleukin-23 inhibitor is aimed at adults with moderate-to-severe...