Methotrexate and alcohol: Tips for you

| Elise Oberliesen

Whether you take beverages shaken, stirred or decanted, mixing alcohol with methotrexate may deliver more than a hangover. Combining the two can create a cocktail muddled with serious side effects, says Junko Takeshita, M.D., Ph.D., with the department of dermatology at the University of Pennsylvania.

"Generally, we know methotrexate can be harmful to the liver, and generally with higher doses and using it for longer [durations] that risk increases," she said.

Methotrexate is often prescribed for moderate to severe psoriasis and psoriatic arthritis. If you are struggling to avoid alcohol while taking methotrexate, here are some things to keep in mind:

Consider the risks. Takeshita said that for people taking methotrexate, risks may worsen for people with hepatitis, fatty liver disease or those who consume alcohol, since these can increase liver damage. Even though some people report drinking alcohol while on the medication, she said "everyone metabolizes methotrexate and alcohol a little differently." And for that reason, it's nearly impossible to speculate whether any amount of alcohol is safe.

Experiment with nonalcoholic drinks. Just talk to someone like Terri Eggeman, who takes methotrexate for her psoriasis and psoriatic arthritis, and it becomes clear: Navigating social situations without booze is a "hot topic." When she's out with friends or colleagues, Eggeman simply orders a sparkling water with a twist of lemon. She says it helps her feel like part of the group while it dissolves any feelings of awkwardness. Of course, turning down alcohol wasn't an issue for Eggeman, since she rarely drank anyway. But that's not the case for everyone.

Be honest with your doctor. Eggemann, who is a Psoriasis One to One mentor and visits online communities like, says it's common for young adults to express frustration about a disease that hampers their lives physically. In fact, some college students forgo methotrexate all together—in favor of medicines with fewer side effects, Eggeman said.

Before the prescription pad comes out, Takeshita asks her patients to be honest about their drinking preferences.

"We take into consideration who to prescribe methotrexate to, especially if a patient says it would be difficult to manage [this medicine] with their current lifestyle," Takeshita said, noting other medications are available for psoriasis and psoriatic arthritis.

Driving discovery, creating community

For more than 50 years, we’ve been driving efforts to cure psoriatic disease and improve the lives of those affected. But there’s still plenty to do! Learn how you can help our advocacy team shape the laws and policies that affect people with psoriasis and psoriatic arthritis – in your state and across the country. Help us raise funds to support research by joining Team NPF, where you can walk, run, cycle, play bingo or create your own fundraising event. If you or someone you love needs free, personalized support for living a healthier life with psoriatic disease, contact our Patient Navigation Center. And keep the National Psoriasis Foundation going strong by making a donation today. Together, we will find a cure.

Recent Advance Posts

Learn how the season can impact your symptoms and what to do to minimize flares.
Offering “byte”-sized medical news updates for health care providers.
Yesterday. Today. Tomorrow.
Jennifer Kerner joins Team NPF to conquer an ultramarathon.
What an Accelerated Medicines Partnership would mean for psoriatic disease.
coronavirus psoriasis psoriatic disease
This group of medical and scientific experts have collaborated to provide...
man woman with psoriasis meet with doctor dermatologist via telehealth telemedicine
Meeting with your health care provider over video or phone can be a successful...
doctor adds data to registry for covid-19 pandemic coronavirus and psoriatic disease psoriasis
Looking to assess the impacts of COVID-19 on those with psoriatic disease.
Nothing spikes your stress like hearing your elderly father has tested positive...