Psoriasis, psoriatic arthritis raise risk of gout

| Melissa Leavitt

People with psoriasis and psoriatic arthritis may need to watch out for signs of gout.

A new study published in Annals of the Rheumatic Diseases finds an increased risk of gout among people with a prior diagnosis of psoriasis or psoriatic arthritis. Gout is an inflammatory disease caused by a buildup of uric acid in the body.

Researchers decided to investigate a possible link between psoriasis and psoriatic arthritis and gout after noticing an overlap in the number of individuals who had both of these conditions, said Dr. Joseph F. Merola, the study’s lead author. “Despite controlling for other risk factors, there appears to be a direct association between psoriasis and psoriatic arthritis and attacks of gout,” Merola said.

The study followed 98,810 people with psoriasis and psoriatic arthritis, and found that 2,217 participants had also been diagnosed with gout. These results indicated that people with psoriasis had 1.71 times the risk of developing gout. The risk was even greater in people with psoriatic arthritis, who were found to be nearly five times as likely to develop gout.

The authors noted that these findings have important clinical implications for the diagnosis and prevention of gout in patients with psoriatic disease.

“Patients who experience sudden onset joint pain should certainly discuss it with their doctor,” said Dr. Abrar Qureshi, a co-author of the study and a member of the National Psoriasis Foundation’s Medical Board. Acute tenderness and inflammation of the joints can be a sign of gout. It is also important to avoid risk factors for gout, such as obesity and alcohol intake, Qureshi said.

One reason behind the heightened risk for gout might be the increased rate of cell turnover that occurs in psoriasis, a process that releases uric acid, Merola explained. Researchers continue to explore the connection between gout and psoriasis, trying to identify the factors linking these conditions together.

“The causal link between psoriasis, psoriatic arthritis, elevated serum uric acid levels, and systemic inflammation remains unclear and is an important area of ongoing investigation,” Merola said.


Driving discovery, creating community

For more than 50 years, we’ve been driving efforts to cure psoriatic disease and improve the lives of those affected. But there’s still plenty to do! Learn how you can help our advocacy team shape the laws and policies that affect people with psoriasis and psoriatic arthritis – in your state and across the country. Help us raise funds to support research by joining Team NPF, where you can walk, run, cycle, play bingo or create your own fundraising event. If you or someone you love needs free, personalized support for living a healthier life with psoriatic disease, contact our Patient Navigation Center. And keep the National Psoriasis Foundation going strong by making a donation today. Together, we will find a cure.

Recent Advance Posts

Let’s get to the bottom of what it really means to be an advocate.
NPF meets with other national health care organizations about access to care...
Dial in to our summer series of advocacy calls and connect with others living...
Patients are looking to 2020 for utilization management reform in the Golden...
Clockwise from left, Brittany Duffy-Goche, Marc Boas, Pete Redding, Tami Seretti, Lisa Bayautet
How patients descended on our nation’s capitol for NPF’s annual fly-in.
Lynne Breaux Arapis
How a lack of good information mobilized one volunteer to get involved and...
Advocacy staff, patient advocates and researchers are ready to raise awareness...
When NPF advocacy brings together many voices with one mission, the results can...
Melissa Leeolou and NPF volunteers Capitol Hill Day 2018
An NPF volunteer uses her own experiences to make a difference for the...