NPF-Funded Research

Interrogating T-Cell Mediated Mechanisms Underlying the Development of Atherosclerosis in Patients With Psoriasis

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Principal Investigator: Patricia Nguyen, M.D.
The Board of Trustees of the Leland Stanford Junior University

Grant Mechanism: Discovery Grant
Funding Amount: $75,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Comorbidity, CVD, Inflammation

Project Summary:

Coronary artery disease (CAD) happens 150% more often in psoriatic patients. Why CAD occurs more often in psoriatic patients remains unclear. We think that the special immune cells called T cells cause both psoriasis and CAD. We think the same trigger activates T cells in both the skin and vessel. We will analyze the T cells in both the skin and aorta of the mice that have psoriasis and CAD. We will then grow “vessels” from stem cells collected from psoriasis patients. We will add the T cells that are specific to the trigger and see if the T cells activate and damage the “vessel”. If we find this trigger causes disease, then we can make treatment to block the trigger.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?

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