NPF-Funded Research

Development of CD8+ Tissue Resident Memory T Cells in Psoriatic Arthritis

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Principal Investigator: Serena Melgrati, Ph.D.
King's College London

Grant Mechanism: Early Career Research Grant
Funding Amount: $17,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriasis, Psoriatic Arthritis, Biologics, Cell Biology, Cell Signaling, Immunology, Inflammation

Project Summary:

Psoriatic arthritis (PsA) is a form of arthritis that develops in up to 30% of patients with psoriasis. Certain immune cells, called T cells, have been found to be important in contributing to inflammation in both the skin and the joints. In particular, some of these T cells remain permanently located (or “resident”) in the inflamed skin and joint, where they continue to drive inflammation leading to disease flares. The aim of this project is to understand how these cells get to these locations and how they become resident. This will inform the development of targeted therapies to stop their function.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?

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