NPF-Funded Research

Degrading CARD14 to Treat Psoriasis

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Principal Investigator: Anne Bowcock, Ph.D.
Icahn School of Medicine at Mount Sinai

Grant Mechanism: Translational Research Grant
Funding Amount: $200,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2026
Status: Active
Keywords: Psoriasis, Animal Models, Drug Therapy, Cell Signaling

Project Summary:

Although biologics have been spectacularly successful they need to be injected and may have long-term effects. We propose a novel approach to psoriasis. We will focus on a protein we identified a few years ago (CARD14) that is central to early alterations arising in psoriatic skin. We will target activated CARD14 for degradation via a novel technology (Bridged-PROTAC). We have identified 29 degraders and will identify additional compounds. We will evaluate their sensitivity and specificity in cell-based systems and animals. We will ultimately evaluate these compounds in animal models of psoriasis, with the long-term goal of taking this to the clinic. This approach could also be applicable to other alterations that arise in psoriasis.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?

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