NPF-Funded Research

Depression and Anxiety in Psoriasis: Mechanisms of Action

Mona Stahle, M.D.

Principal Investigator: Mona Stahle, M.D.
Institution:
Karolinska Institutet


Grant Mechanism: More Than Skin Deep: Mental Health Grant
Funding Amount: $100,000
Project Start Date: August 1, 2022
Project End Date: August 1, 2023
Status: Concluded
Keywords: Psoriasis, Comorbidity, Mental Health, Biomarkers

Project Summary:

The association between psoriasis and depression has been recognized and reported for several years. The underlying biology however remains unclear. Is it the burden and stigmatization of psoriasis that results in mood disorder or are additional yet unknown factors at play. The overall aim of our project is to open up a new biological approach in studying depression in patients with severe psoriasis following their symptoms over time while exploring inflammatory profiles and pathways. We realize that this may only be the first steps in this direction but may hopefully lead to more insight into mechanisms and help improve therapy.

Publications

Interleukin 17 and Interleukin 23 Inhibitors Associated with Direct Effect on Depressive Symptoms: Results from a Register Study

Read the article

Itch is More Important than Clinical Disease Severity for Depression in Psoriasis: A Prospective Register Study

Read the article

Researcher Profile:

Dr. Mona Stahle's research is part of the Karolinska Psoriasis Center which is the clinical base for treatment of psoriasis patients who need systemic treatments to control their disease. The psoriasis team includes clinicians, senior scientists, post-docs, graduate students, and nurses. Several team members share their time between the laboratory and the clinic which enables a truly translational approach.


This More than Skin Deep: Mental Health Grant was made possible by contributions from the Fairfield County’s Community Foundation Fred and Joan Weisman Fund and the Thomas Andrew Speaker Memorial Fund.

Impact of NPF-Funded Research

The NPF has awarded over $30 million in research funding in recent years, with immeasurable impact on our community.

Read more

We Need Your Help

With your gift we can fund even more research to get better treatment and diagnostic options and someday, a cure.

Help fund critical research

NPF-Funded Research

Discover our other active research projects.

Learn more

Stay in the Know

Expert tips, can’t-miss events, and the latest news, straight to your inbox.

National Health Council Standards of ExcellenceCharity NavigatorCommunity Health Charities logo

Copyright © 1996-2024 National Psoriasis Foundation/USA


Duplication, rebroadcast, republication, or other use of content appearing on this website is prohibited without written permission of the National Psoriasis Foundation (NPF).


NPF does not endorse or accept any responsibility for the content of external websites.


NPF does not endorse any specific treatments or medications for psoriasis and psoriatic arthritis.

We use cookies to offer you a better experience and analyze our site traffic. By continuing to use this website, you consent to the use of cookies in accordance with our Privacy Policy.