NPF-Funded Research

GLUT1 Inhibition by Lipid Nanoparticle (LNP) siRNA and Phloretin as Novel Treatments for Psoriasis

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Principal Investigator: Richard Wang, M.D., Ph.D.
The University of Texas Southwestern Medical Center (UT Southwestern)

Grant Mechanism: Discovery Grant
Funding Amount: $75,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriasis, Animal Models, Disease Etiology, Drug Therapy, Disease Models, Immunology

Project Summary:

The GLUT1 glucose transporter is overexpressed in psoriasis. We previously found that its deletion prevented psoriasis in mouse models. We will advance GLUT1 inhibition as a therapeutic target in patients in two ways. First, we will develop novel lipid nanoparticles (LNPs) to deliver small-interfering RNA (siRNAs) to target GLUT1 and then test them in mouse models of psoriasis. Second, we will test whether phloretin, currently sold as a topical antioxidant, may also function as a GLUT1 transport inhibitor and novel treatment for psoriasis. This proposal has the potential to identify new therapies for psoriasis patients, broaden our understanding of psoriasis, and provide preliminary data for funding from other agencies.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?

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