NPF-Funded Research

GLUT1 Inhibition by Lipid Nanoparticle (LNP) siRNA and Phloretin as Novel Treatments for Psoriasis

Headshot to be 275 x 275 px

Principal Investigator: Richard Wang, M.D., Ph.D.
Institution:
The University of Texas Southwestern Medical Center (UT Southwestern)


Grant Mechanism: Discovery Grant
Funding Amount: $75,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriasis, Animal Models, Disease Etiology, Drug Therapy, Disease Models, Immunology

Project Summary:

The GLUT1 glucose transporter is overexpressed in psoriasis. We previously found that its deletion prevented psoriasis in mouse models. We will advance GLUT1 inhibition as a therapeutic target in patients in two ways. First, we will develop novel lipid nanoparticles (LNPs) to deliver small-interfering RNA (siRNAs) to target GLUT1 and then test them in mouse models of psoriasis. Second, we will test whether phloretin, currently sold as a topical antioxidant, may also function as a GLUT1 transport inhibitor and novel treatment for psoriasis. This proposal has the potential to identify new therapies for psoriasis patients, broaden our understanding of psoriasis, and provide preliminary data for funding from other agencies.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?






Researcher Profile:

Impact of NPF-Funded Research

The NPF has awarded over $30 million in research funding in recent years, with immeasurable impact on our community.

Read more

We Need Your Help

With your gift we can fund even more research to get better treatment and diagnostic options and someday, a cure.

Help fund critical research

NPF-Funded Research

Discover our other active research projects.

Learn more

Stay in the Know

Expert tips, can’t-miss events, and the latest news, straight to your inbox.

National Health Council Standards of ExcellenceCharity NavigatorCommunity Health Charities logo

Copyright © 1996-2024 National Psoriasis Foundation/USA


Duplication, rebroadcast, republication, or other use of content appearing on this website is prohibited without written permission of the National Psoriasis Foundation (NPF).


NPF does not endorse or accept any responsibility for the content of external websites.


NPF does not endorse any specific treatments or medications for psoriasis and psoriatic arthritis.

We use cookies to offer you a better experience and analyze our site traffic. By continuing to use this website, you consent to the use of cookies in accordance with our Privacy Policy.