NPF-Funded Research

The Role of Group A Streptococcus-Derived, HLA-C*06:02-Restricted Antigens in Psoriasis

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Principal Investigator: Runqiu Song, M.Bio.H.Sc.
Institution:
Monash University


Grant Mechanism: Early Career Research Grant
Funding Amount: $50,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriasis, Animal Models, Cell Biology, Genetics, Cell Signaling

Project Summary:

The risk of developing psoriasis is linked to genetics and environmental triggers, including bacterial infections. We hypothesize that there is a direct link between the main risk gene HLA-C6 and common Streptococcal throat infections. We believe that the HLA-C6-led immune response against Streptococci can cause a misguided recruitment of immune cells to the skin where they wreak havoc and cause psoriasis. This proposal aims to find Streptococcal immune targets presented by HLA-C6 and to verify any T cell responses against such targets. Identifying bacterial triggers of psoriasis and understanding their similarity to molecules in the skin opens up new therapeutical avenues to develop long-lasting tolerizing and remission-inducing therapies.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?






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