NPF-Funded Research

The Role of Group A Streptococcus-Derived, HLA-C*06:02-Restricted Antigens in Psoriasis

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Principal Investigator: Runqiu Song, M.Bio.H.Sc.
Monash University

Grant Mechanism: Early Career Research Grant
Funding Amount: $50,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriasis, Animal Models, Cell Biology, Genetics, Cell Signaling

Project Summary:

The risk of developing psoriasis is linked to genetics and environmental triggers, including bacterial infections. We hypothesize that there is a direct link between the main risk gene HLA-C6 and common Streptococcal throat infections. We believe that the HLA-C6-led immune response against Streptococci can cause a misguided recruitment of immune cells to the skin where they wreak havoc and cause psoriasis. This proposal aims to find Streptococcal immune targets presented by HLA-C6 and to verify any T cell responses against such targets. Identifying bacterial triggers of psoriasis and understanding their similarity to molecules in the skin opens up new therapeutical avenues to develop long-lasting tolerizing and remission-inducing therapies.

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