NPF-Funded Research

Immune Cell Contributions to Inflammatory Arthritis

Headshot to be 275 x 275 px

Principal Investigator: Nicole L. Ward, Ph.D.
Institution:
Vanderbilt University Medical Center (VUMC)


Grant Mechanism: R01 Bridge Grant
Funding Amount: $100,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriatic Arthritis, Comorbidity, Inflammation, Immunology, Disease Models, Cell Biology

Project Summary:

Psoriatic arthritis is a debilitating yet poorly understood joint disease that affects ~1 million Americans. Using a newly engineered mouse model of psoriatic arthritis, joint tissues from psoriasis patients, and cutting-edge transcriptomics technologies, we will determine whether B cells, a class of immune cells long overlooked in the psoriasis field, are essential drivers of psoriatic arthritis. The results of this research will bring clarity to the longstanding questions of how psoriatic arthritis arises, why it does not respond to many of our current therapies for psoriasis of the skin, and what existing FDA-approved agents may be repurposed to treat this devastating disease.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?






Researcher Profile:

Impact of NPF-Funded Research

The NPF has awarded over $30 million in research funding in recent years, with immeasurable impact on our community.

Read more

We Need Your Help

With your gift we can fund even more research to get better treatment and diagnostic options and someday, a cure.

Help fund critical research

NPF-Funded Research

Discover our other active research projects.

Learn more

Stay in the Know

Expert tips, can’t-miss events, and the latest news, straight to your inbox.

National Health Council Standards of ExcellenceCharity NavigatorCommunity Health Charities logo

Copyright © 1996-2024 National Psoriasis Foundation/USA


Duplication, rebroadcast, republication, or other use of content appearing on this website is prohibited without written permission of the National Psoriasis Foundation (NPF).


NPF does not endorse or accept any responsibility for the content of external websites.


NPF does not endorse any specific treatments or medications for psoriasis and psoriatic arthritis.

We use cookies to offer you a better experience and analyze our site traffic. By continuing to use this website, you consent to the use of cookies in accordance with our Privacy Policy.