NPF-Funded Research

Immune Cell Contributions to Inflammatory Arthritis

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Principal Investigator: Nicole L. Ward, Ph.D.
Vanderbilt University Medical Center (VUMC)

Grant Mechanism: R01 Bridge Grant
Funding Amount: $100,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriatic Arthritis, Comorbidity, Inflammation, Immunology, Disease Models, Cell Biology

Project Summary:

Psoriatic arthritis is a debilitating yet poorly understood joint disease that affects ~1 million Americans. Using a newly engineered mouse model of psoriatic arthritis, joint tissues from psoriasis patients, and cutting-edge transcriptomics technologies, we will determine whether B cells, a class of immune cells long overlooked in the psoriasis field, are essential drivers of psoriatic arthritis. The results of this research will bring clarity to the longstanding questions of how psoriatic arthritis arises, why it does not respond to many of our current therapies for psoriasis of the skin, and what existing FDA-approved agents may be repurposed to treat this devastating disease.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?

Researcher Profile:

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