NPF-Funded Research

Exploring the Impact of Immune-Mediated Lipolysis on the Pathophysiology of Psoriasis

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Principal Investigator: Monika Bambouskova, Ph.D.
Institution:
Washington University in St.Louis


Grant Mechanism: Discovery Grant
Funding Amount: $75,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Comorbidity, Psoriasis, Immunology, Metabolic Diseases, Inflammation, Diet, Cell Signaling

Project Summary:

Psoriasis is a chronic skin condition with severe impact of human life. The increasing incidence of obesity, a major health concern worldwide, is closely linked to a higher risk of developing psoriasis. Importantly, being obese can make standard anti-inflammatory treatments for psoriasis less effective. Our research focuses on how the body's metabolism works together with the immune system and our preliminary data suggest a novel connection between lipid metabolism and psoriasis. In this proposal, we aim to explore the contribution of immune-regulated fat breakdown to how psoriasis starts and how severe it becomes, especially in people dealing with obesity.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?






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