NPF-Funded Research

Identifying Metabolomic Markers of Disease Activity in Psoriatic Arthritis

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Principal Investigator: Vinod Chandran, D.M., Ph.D.
University Health Network

Grant Mechanism: Translational Research Grant
Funding Amount: $199,510
Project Start Date: August 1, 2024
Project End Date: July 31, 2026
Status: Active
Keywords: Psoriatic Arthritis, Biomarkers, Multi-omics

Project Summary:

It is important to accurately determine whether PsA patients are in low, moderate, or high disease activity so that treatment is appropriately tailored. However, current methods of assessing disease activity are imprecise. Our purpose is to confirm whether small molecules (metabolites) that we have previously identified reliably measure PsA disease activity. We aim to comprehensively analyze three datasets to identify high-priority metabolites and develop blood tests to quantify these metabolites. We will then confirm if these metabolites are able to accurately measure PsA disease activity over time. A test based on these metabolites will better measure PsA disease activity, leading to better outcomes for patients.

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