NPF-Funded Research

Sex Differences in Cellular Immune Profiles in Psoriatic Arthritis

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Principal Investigator: Steven Dang, B.Sc.
Women's College Hospital

Grant Mechanism: Early Career Research Grant
Funding Amount: $50,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriatic Arthritis, Biomarkers

Project Summary:

Psoriatic arthritis (PsA) affects males and females differently, with females more likely to stop drug therapy earlier due to poor effectiveness and increased side effects. We aim to identify immune and inflammatory factors behind the differences in the disease course and treatment response between males and females with PsA. Using advanced mass cytometry technology, which will help to characterize the type of immune cells involved in PsA, we will analyze blood samples from patients before and after they begin treatment. We will study whether there are differences between the sexes in the immune cells that determine response to treatment. This knowledge will support the development of sex-specific tools to improve the lives of PsA patients.

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