NPF-Funded Research

Longitudinal Relationships Among Sleep Health, Systemic Inflammation, and Disease Activity in Psoriatic Arthritis

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Principal Investigator: Lourdes Perez Chada, M.D.
Brigham and Women's Hospital, Inc.

Grant Mechanism: R01 Bridge Grant
Funding Amount: $50,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Comorbidity, Psoriatic Arthritis, Clinical Research, Inflammation, Immunology, Mental Health

Project Summary:

A good night’s sleep is an unmet goal for many patients with psoriatic arthritis. Good control of disease activity (i.e., skin and joint symptoms) is also difficult for these patients. Sleep and disease activity may affect each other. For example, patients with psoriatic arthritis mentioned that after a bad night’s sleep, their painful joints were worse and that their joint pain caused nighttime awakenings. However, no studies have examined these sleep-disease activity relationships in detail or over time. We will explore the relationships between sleep, inflammation, and disease activity in patients with psoriatic arthritis over 1 year. This data will help us explore treatments targeting better sleep to lessen psoriatic arthritis activity.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?

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