NPF-Funded Research

An Integrated Single-Cell and Spatial-Transcriptomic Analysis of Synovial Inflammation in Psoriatic Arthritis

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Principal Investigator: Ryan Malcolm Hum, MBChB, MRCP(UK)
Institution: University of Manchester

Grant Mechanism: Psoriatic Disease Research Fellowship
Funding Amount: $49,710
Project Start Date: July 1, 2024
Project End Date: June 30, 2025
Status: Active
Keywords: Psoriatic Arthritis, Psoriasis, Cell Biology, Computational Biology, Gene Expression, Multi-omics Immunology

Project Summary:

Psoriatic arthritis (PsA), a prevalent form of inflammatory arthritis, impacts roughly one-third of individuals with psoriasis and leads to significant health challenges when left untreated. Despite available treatments, as many as half of patients still experience ongoing inflammation. Therefore, there's a critical need for research to better understand and treat this condition. My project involves gathering tissue, fluid, and blood samples from PsA patients with inflamed joints detected through ultrasound. Using the latest technologies called CITE-seq and spatial transcriptomics, I will analyze these samples at the single-cell level to identify specific cell populations and new targets for therapy and markers to monitor disease activity.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?

Researcher Profile:

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