NPF-Funded Research

An Integrated Single-Cell and Spatial-Transcriptomic Analysis of Synovial Inflammation in Psoriatic Arthritis

Icon of a doctor - Kopa.

Principal Investigator: Ryan Malcolm Hum, MBChB, MRCP(UK)
Institution: University of Manchester


Grant Mechanism: Psoriatic Disease Research Fellowship
Funding Amount: $49,710
Project Start Date: July 1, 2024
Project End Date: June 30, 2025
Status: Active
Keywords: Psoriatic Arthritis, Psoriasis, Cell Biology, Computational Biology, Gene Expression, Multi-omics Immunology

Project Summary:

Psoriatic arthritis (PsA), a prevalent form of inflammatory arthritis, impacts roughly one-third of individuals with psoriasis and leads to significant health challenges when left untreated. Despite available treatments, as many as half of patients still experience ongoing inflammation. Therefore, there's a critical need for research to better understand and treat this condition. My project involves gathering tissue, fluid, and blood samples from PsA patients with inflamed joints detected through ultrasound. Using the latest technologies called CITE-seq and spatial transcriptomics, I will analyze these samples at the single-cell level to identify specific cell populations and new targets for therapy and markers to monitor disease activity.

How will your project help improve the lives of the 125 million affected by psoriatic disease?

Why is psoriatic disease research important to you, personally? What role will this award play in your research efforts or career development?







Researcher Profile:

Impact of NPF-Funded Research

The NPF has awarded over $30 million in research funding in recent years, with immeasurable impact on our community.

Read more

We Need Your Help

With your gift we can fund even more research to get better treatment and diagnostic options and someday, a cure.

Help fund critical research

NPF-Funded Research

Discover our other active research projects.

Learn more

Stay in the Know

Expert tips, can’t-miss events, and the latest news, straight to your inbox.

National Health Council Standards of ExcellenceCharity NavigatorCommunity Health Charities logo

Copyright © 1996-2024 National Psoriasis Foundation/USA


Duplication, rebroadcast, republication, or other use of content appearing on this website is prohibited without written permission of the National Psoriasis Foundation (NPF).


NPF does not endorse or accept any responsibility for the content of external websites.


NPF does not endorse any specific treatments or medications for psoriasis and psoriatic arthritis.

We use cookies to offer you a better experience and analyze our site traffic. By continuing to use this website, you consent to the use of cookies in accordance with our Privacy Policy.