NPF-Funded Research

Transcriptional Regulation of Synovial Tissue Resident Memory CD8 T Cells

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Principal Investigator: Paul Hsu, M.D., Ph.D.
The Regents of the University of California, San Diego

Grant Mechanism: Early Career Research Grant
Funding Amount: $50,000
Project Start Date: August 1, 2024
Project End Date: July 31, 2025
Status: Active
Keywords: Psoriatic Arthritis, Animal Models, Cell Biology, Disease Models, Immunology

Project Summary:

Psoriatic arthritis (PsA) is an autoimmune disease characterized by chronic joint pain, swelling, and damage and recurring flares of synovial inflammation. While new treatments are highly effective in treating PsA, most patients do not reach remission or are refractory to multiple lines of treatment. Recurrent flares are thought to be due to tissue-resident memory CD8+ T cells (TRM) that remain within the affected joints and skin. The cellular programming that instructs TRM to accumulate and stay in joints. FOXO1 is a transcription factor that is important for memory T cells, and controls the balance of resting and active cells. Understanding how FOXO1 controls synovial TRM and inflammatory arthritis may provide new strategies to treat PsA.

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