The Future of Psoriasis Care: Dr. Mona Shahriari Breaks Down New AAD Research & Personalized Treatments

Transcript

Guest Speaker

Mona Shahriari, M.D.

Title

Dermatologist and Associate Director of Clinical Trials
Central Connecticut Dermatology

Moderator

Archie Franklin

Title

NPF Volunteer and Patient Advocate

Explore groundbreaking updates in psoriasis and psoriatic arthritis research from the 2025 AAD Annual Meeting with dermatologist Dr. Mona Shahriari.

Join host Archie Franklin and renowned dermatologist Dr. Mona Shahriari as they unpack the latest research and clinical insights into managing psoriatic disease. This episode dives into head-to-head therapeutic trials, fast-acting treatments for high-impact areas like scalp and nails, and a preview of emerging oral systemics and GLP-1 weight management therapies. Dr. Shahriari discusses real-world challenges in treating psoriasis and psoriatic arthritis, the rise of precision medicine, and how early intervention could alter disease progression.

Whether you're a patient, clinician, or researcher, this conversation delivers critical updates on psoriasis care, including IL-17, IL-23, and TYK2 inhibitors, and their potential to revolutionize dermatology practice.

4 Key Takeaways:

Head-to-head trials show IL-17s like ixekizumab outperform traditional TNF inhibitors and even some IL-23s in early, fast action.
Precision therapy based on site (scalp, nails, genitalia) and comorbidities is now guiding real-world treatment selection.
GLP-1 medications are emerging as effective adjuncts for psoriasis patients struggling with weight and inflammation.
Early intervention—especially with IL-23 blockers—may reduce flares, limit disease progression, and improve mental health outcomes.

Dr. Mona Shahriari's Bio

Dr. Mona Shahriari is an Associate Clinical Professor of Dermatology at Yale University and Co-Founder of Central Connecticut Dermatology. A leading voice in inflammatory skin conditions, she serves as Associate Director of Clinical Trials and Senior Editor for the Journal of Psoriasis and Psoriatic Arthritis. Dr. Shahriari is also a National Psoriasis Foundation Medical Board Member and frequent contributor to dermatological research and clinical education.

Resources Mentioned

National Psoriasis Foundation: https://www.psoriasis.org
Subscribe to the Advance eNewsletter: https://www.psoriasis.org/subscribe
AAD Annual Meeting Info: https://www.aad.org
Learn More About Clinical Trials: https://clinicaltrials.gov

Episode Timestamps

(00:00) Intro to Psound Bytes & guest welcome Dr. Mona Shahriari
(01:00) What the AAD 2025 conference revealed about psoriatic disease
(02:10) Comparing IL-17 and IL-23 inhibitors: Trial results
(06:00) Treating scalp, palmoplantar, and nail psoriasis
(10:45) Genital psoriasis & the importance of psychosocial care
(12:00) What’s new for Generalized Pustular Psoriasis (GPP)
(14:35) The GUIDE Study: Early treatment & immune memory
(18:00) Personalized medicine, oral IL-23s & emerging TYK2s
(20:00) GLP-1 therapies for weight & inflammation control
(23:00) Psoriasis, cardiovascular risk & comorbidities
(24:00) Mental health, depression & the value of systemic treatment
(26:00) A hopeful future: matching therapy to the patient

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The Future of Psoriasis Care: Dr. Mona Shahriari Breaks Down New AAD Research & Personalized Treatments

Guest Speaker

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Moderator

Title

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Dr. Mona Shahriari's Bio

Resources Mentioned

Episode Timestamps

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