Traditional systemic medications

Systemic medications, aimed at those with moderate to severe psoriasis and psoriatic disease, are prescription drugs that work throughout the body. They are also used in those who are not responsive or are unable to take topical medications or UV light therapy.

Systemic psoriasis drugs have been around for more than 10 years and are taken by mouth in liquid or pill form or given by injection.

Treatment Comparison Chart

Learn more about traditional systemics

Get the facts on systemic medications

NPF’s systemic treatment booklet will help you navigate systemic treatments and provide you with a comprehensive breakdown on some of the more popular systemic medications on the market today.

Test your treatment IQ

How much do you know about your psoriatic disease treatment options? Put your knowledge to the test with our treatment quiz and let NPF help you fill in some of the gaps.


Last updated  by the National Psoriasis Foundation.