Cardiovascular disease the leading cause of death for PsA 

| Emily Delzell

People with severe psoriatic arthritis have a much higher risk of developing both metabolic syndrome – a cluster of cardiovascular risk factors including high blood pressure and abdominal obesity—and insulin resistance, which is an early sign of diabetes, according to findings from a recent study.

“Both metabolic syndrome and insulin resistance increase risk for heart attack and stroke, and cardiovascular diseases are the top leading cause of mortality in patients with psoriatic arthritis,” said Dr. Muhammad Haroon, co-author of the study, published in July in The Journal of Rheumatology.

“We believe the chronic inflammation of psoriatic arthritis drives development of these conditions, which our findings show are very common among people with psoriatic arthritis,” he said.

Study investigators recruited 283 patients with psoriatic arthritis and tested them for metabolic syndrome and insulin resistance, diagnosing 44 percent with metabolic syndrome and 16 percent with insulin resistance.

Metabolic syndrome, which causes chronic low-grade inflammation, is diagnosed when people have three of five well-known cardiovascular risk factors: high blood pressure, blood sugar, triglyceride and cholesterol levels, and a waist circumference greater than 40 inches in men and greater than 35 inches women. Insulin resistance occurs when the body produces the hormone insulin, but can’t use it effectively.

The researchers found high rates of metabolic syndrome symptoms among all patients studied: 74 percent had high blood pressure, 56 percent had an elevated waist circumference, and 43.5 percent had high triglycerides. In addition, doctors diagnosed half the patients with four or more symptoms of metabolic syndrome. 

Researchers found that people who developed psoriasis and psoriatic arthritis later in life and those who progressed from skin involvement to psoriatic arthritis more quickly had higher rates of metabolic syndrome and insulin resistance, as did smokers and those with more severe psoriatic arthritis.

All patients were newly diagnosed with metabolic syndrome and insulin resistance. Haroon noted that while screening for these conditions among people with psoriasis and psoriatic arthritis should be part of routine health care, most primary care, dermatology and rheumatology practices aren’t doing that.

People with psoriasis and psoriatic arthritis should ask their doctors about risks and request screening, Haroon said. “Patient education is vital and may be the most fruitful tool in assessing and managing cardiovascular risks.”

Treating metabolic syndrome and insulin resistance lowers cardiovascular disease risk, and may also reduce psoriatic disease activity, though more research is needed to confirm this and determine which treatments might help, he said.


Driving discovery, creating community

For more than 50 years, we’ve been driving efforts to cure psoriatic disease and improve the lives of those affected. But there’s still plenty to do! Learn how you can help our advocacy team shape the laws and policies that affect people with psoriasis and psoriatic arthritis – in your state and across the country. Help us raise funds to support research by joining Team NPF, where you can walk, run, cycle, play bingo or create your own fundraising event. If you or someone you love needs free, personalized support for living a healthier life with psoriatic disease, contact our Patient Navigation Center. And keep the National Psoriasis Foundation going strong by making a donation today. Together, we will find a cure.

Recent Advance Posts

Jon and his big sister Brenda Kong
Brenda Kong is all too familiar with managing the chronic pain that comes with...
NPF patient advocates educate Congress about Medicare access challenges.
Surprise! Our guest contributor from across the pond finds a silver lining in a...
woman with dark wet hair getting a comb out
The right scalp psoriasis treatment can help you live healthier – and look...
affectionate man and woman in back yard
A dermatologist answers questions on how psoriasis and psoriatic arthritis may...
Seated person close-up of clasped hands
The right treatment can ease the skin and the mind in unexpected ways.
data streams
Here’s a look at how scientists are advancing psoriatic disease research,...
The experts weigh in on how to have a happy Team NPF Walk experience despite...
Your disease may be affecting you in more ways than you think