Related Conditions of Psoriatic Arthritis

Those living with psoriatic arthritis are also at risk of developing related health conditions (known as comorbidities), like heart disease, diabetes, and obesity. Evidence shows that people who effectively treat psoriatic arthritis can also lower the risk of other comorbidities.

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Health Conditions Linked to Psoriatic Arthritis

It is important to visit your primary care provider regularly to screen for these diseases because you may not notice or feel symptoms for some of these health conditions. In addition, if some of these conditions are caught early, they can be easily treated with lifestyle changes or medications.

Evidence shows that people who effectively treat psoriatic arthritis (PsA) can also lower the risk of other comorbidities.

In 2019, the National Psoriasis Foundation and the American Academy of Dermatology published guidelines on the treatment of psoriasis with attention to comorbidities. The guidelines state the following health conditions as comorbidities of PsA. People living with PsA are at risk for the same comorbidities as psoriasis.


Psoriasis is an inflammatory disease that presents on the skin in plaques and scales but also can lead to inflammation in other parts of the body. Not everyone with PsA has or will develop psoriasis. An estimated 30 percent of people with psoriasis develop PsA.

Cardiovascular Disease

Cardiovascular disease (also known as heart disease) refers to numerous conditions including heart attack, stroke, heart failure, arrhythmia (irregular heart rhythm), and heart valve problems.

Metabolic Syndrome

Metabolic syndrome refers to the presence of increased blood pressure, high blood sugar, excess body fat, and abnormal cholesterol levels, which increase the risk of heart disease, stroke, and type 2 diabetes.


Obesity is a complex chronic disease involving genetic and environmental factors. Obesity is defined as too much body fat (especially around the waist) that presents a health risk. Obesity may increase the risk of chronic diseases such as cardiovascular disease, diabetes, and cancer. Body Mass Index (BMI) uses a person’s height and weight to determine obesity. A person with a BMI of 30 or more is generally considered to have obesity.


Hypertension is another name for high blood pressure, which refers to the pressure of blood pushing against the walls of the arteries. Hypertension is very common and increases the risk of cardiovascular disease and stroke.


Dyslipidemia refers to having consistently high levels of cholesterol and other lipids (also called fats) in the blood. Dyslipidemia may increase the risk of cardiovascular disease.


Type 2 diabetes (also called insulin resistance) refers to cells in the body that do not respond normally to insulin. Normally insulin works to let blood sugar into the cells in the body to use as energy. Type 2 diabetes may increase the risk of cardiovascular disease, vision loss, and kidney disease.

Anxiety and Depression

People with anxiety disorders often struggle with intense feelings of anxiety, worry, fear, and/or panic. Anxiety can interfere with daily activities and may last a long time. People with depression experience a persistent sad mood that lasts a long time and interferes with daily activities.

Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) refers to conditions characterized by inflammation in the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.


Cancer describes diseases in which abnormal cells divide without control and may spread into nearby tissue. There are more than 100 types of cancers and are often named after the area in the body where the cancer forms.

Kidney Disease

Chronic kidney disease occurs when the kidneys are damaged or cannot filter blood as well as normal kidneys. As a result, extra fluid and waste from the blood stay in the body and may lead to other health problems.

Sleep Apnea

Sleep apnea is a potentially serious sleep disorder in which breathing repeatedly stops and starts during sleep. This happens when the muscles in the throat relax, blocking the airway.

Chronic Obstructive Pulmonary Disease (COPD)

Chronic obstructive pulmonary disease refers to a group of diseases that cause breathing-related problems and airflow blockage.


Uveitis refers to inflammation in the eye which affects the middle layer of tissue in the eye wall (uvea). Symptoms include eye redness, pain, and blurred vision, and symptoms may come on suddenly and progress quickly.

Hepatic (Liver) Disease

Hepatic disease refers to inflammation of the liver that disrupts the liver’s function and which can lead to permanent kidney damage.

Comorbidities Quick Guide

Learn more about comorbidities and ways to lower your risk. And, for those living with chronic pain due to psoriatic arthritis, request our free Chronic Pain Kit to best manage it.

Get our free quick guide

Last updated on 12/22/2023 by the National Psoriasis Foundation.

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