National Psoriasis Foundation

Psoriasis Forum Journal

Psoriasis Forum, a peer review journal, published quarterly by the National Psoriasis Foundation, Psoriasis Forum is the only publication of its kind—dedicated to providing up-to-date and practical information to health care providers on the front line of psoriasis and psoriatic arthritis treatment.

Psoriasis Forum is sent to professional members of the Psoriasis Foundation.

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Current issue: Fall 2014 Vol. 20, No. 3

Featured article

Treatment of Refractory Psoriasis with Ustekinumab in an HIV -Positive Patient: A Case Presentation and Review of the Biologic Literature

Shira Wieder, B.A., Ethan Routt, B.A., Jacob Levitt, M.D., Mark Lebwohl, M.D.

Here we describe a case of a 39-year-old male with HIV and a 20-year history of generalized plaque psoriasis and psoriatic arthritis. The patient had been refractory to all treatments until initiating ustekinumab, the monoclonal antibody against IL-12/23. While using ustekinumab, the patient’s CD4 T-cell count and HIV viral load have remained stable. Due to the questions surrounding the use of biologics in HIV-positive patients, we review the successful use of anti-TNF agents in patients with chronic HIV infection as well as the single other reported case of ustekinumab’s use in an HIV-positive patient. We therefore begin to build the case for ustekinumab as an alternative biologic therapy for the HIV-infected psoriasis patient.

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Also in this issue:

  • Safety and Efficacy of Cyclosporine in Psoriatic Arthritis
  • Tonsillectomy and Antistreptococcal Interventions for Psoriasis: A Review
  • Influence of Cutaneous Involvement in Deciding How to Treat Psoriatic Arthritis

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