Potential new solution for nail psoriasis

| Melissa Leavitt

Treating nail psoriasis can be, well, as tough as nails. Research shows that up to 55 percent of people with psoriasis may have nail involvement. In many cases, symptoms of nail psoriasis, like pitting and crumbling, can also be a warning sign of psoriatic arthritis.

Topical treatments or steroid injections can be two treatment options for nail psoriasis. According to research presented at the 2016 American Academy of Dermatology meeting in Washington, D.C., another treatment may be in the works.

A group of researchers from Greece and Switzerland reported on trial results testing a new way of managing nail psoriasis that puts familiar psoriasis treatments in a solution designed specifically for nails.

The Phase II trial enrolled almost 80 patients, having them use one of two psoriasis nail solutions or a placebo treatment once a day for about six months. Patients had to have mild-to-moderate psoriasis, with psoriasis on at least one fingernail.

One treatment contained cyclosporine while the other contained the vitamin D-based treatment calcipotriene. 

At the end of the study, researchers found that the calcipotriene-based solution delivered the greatest improvement in nail psoriasis. The cyclosporine treatment helped the nail bed but not the nail matrix, which is the part of the nail located under the skin.

According to the results, the nail solutions were also deemed safe for patients in that no patients in any treatment group had a serious side effect, and no patients withdrew from the study because of a side effect.

Based on the findings, the researchers concluded that the calcipotriene-based nail solution should be further developed and tested in clinical trials. A Phase III trial for the treatment, known as P-3073, is recruiting.


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