Psoriasis-clearing drug gets FDA approval

| Melissa Leavitt

A new psoriasis drug that’s delivered dramatic skin improvement has been approved by the Food and Drug Administration (FDA).

Cosentyx (secukinumab), an injectable biologic drug manufactured by Novartis, has won approval for the treatment of chronic plaque psoriasis. In clinical trials, more than half of patients taking Cosentyx experienced clear or almost clear skin, while the majority experienced significant improvement.

In one trial, more than a quarter of patients achieved a 100 percent improvement in their skin, as measured by the Psoriasis Area and Severity Index. This measurement, also known as PASI 100, means that the patient had no psoriasis anywhere on their body. Almost 82 percent of patients in the same trial achieved 75 percent improvement, or PASI 75.

Other data on the drug indicate that the level of improvement delivered by Cosentyx can be long-lasting.

Results from another Phase III trial suggest that Cosentyx is also an effective treatment for psoriatic arthritis. Novartis plans to apply for FDA approval for Cosentyx as a psoriatic arthritis drug later this year.

Cosentyx targets interleukin-17A (IL-17A), which is a protein, or cytokine, that triggers inflammation. IL-17 is a key cytokine in psoriasis, and, according to the researchers, may even be a “master cytokine,” responsible for a series of inflammatory reactions.

Two other drugs targeting IL-17, brodalumab and ixekizumab, are also being developed as treatments for psoriasis.


Driving discovery, creating community

For more than 50 years, we’ve been driving efforts to cure psoriatic disease and improve the lives of those affected. But there’s still plenty to do! Learn how you can help our advocacy team shape the laws and policies that affect people with psoriasis and psoriatic arthritis – in your state and across the country. Help us raise funds to support research by joining Team NPF, where you can walk, run, cycle, play bingo or create your own fundraising event. If you or someone you love needs free, personalized support for living a healthier life with psoriatic disease, contact our Patient Navigation Center. And keep the National Psoriasis Foundation going strong by making a donation today. Together, we will find a cure.

Recent Advance Posts

doctor facing patient across desk
The Corrona Psoriasis Registry will give health care providers the data needed...
Charlotte Community
Researcher Charlotte Hurabielle-Claverie, M.D., finds joy in unraveling the...
hand with arthritis on mouse beside keyboard
We take many common movements and activities for granted – until they become...
Shujahn family
Derek Schujahn turns helplessness into motivation and raises money for NPF in...
Psoriasis sunscreen tips
Just in time for summer, expert tips to help you stay safe in the sun.
Stephen Katz
Six longtime members of our community remember Stephen I. Katz, M.D., Ph.D., a...
Patients are looking to 2020 for utilization management reform in the Golden...
Michelle Strangis
NPF volunteer Michelle Strangis has employed her decades of law expertise to...
genital psoriasis
One in four of you will experience genital psoriasis. Relief starts with having...