NPF-Funded Research

Pre-diagnostic Plasma Metabolites and Risk of Psoriasis

Headshot to be 275 x 275 px

Grantee: Sara Ragi
Mentor: Eunyoung Cho, Sc.D.
Brown University

Grant Mechanism: Summer Student Research Grant
Funding Amount: $5,000
Project Start Date: May 15, 2023
Project End Date: July 24, 2023
Status: Active
Keywords: Psoriasis, Clinical Research, Biomarkers, Epidemiology, Prevention

Project Summary:

Psoriasis is a complex immune-mediated disease with a prevalence of 3% in the United States and representing 84.1% of medical dermatology visits in North America. Psoriasis has a multifactorial etiology involving the interaction of genetic, metabolic, and environmental factors. We propose conducting a metabolomic analysis in a nested case-control study including 264 psoriasis cases and 9,326 controls within two large, ongoing prospective cohorts of female registered nurses. We seek to clarify the role of metabolite levels and dysregulation in metabolic pathways in the pathogenesis of psoriasis as the biological mechanisms by which circulating metabolites affect psoriatic disease risk remain unknown. Identifying increased or decreased biomarkers of psoriatic disease may enable enhanced screening guidelines and opportunities for a cure. Establishing the metabolic alterations of psoriasis may help in primary prevention, and facilitate earlier diagnosis and subsequent interventions. The objectives of our study are to characterize a wide range of plasma metabolome alterations in psoriasis patients and provide new insights into the pathomechanisms of psoriatic disease.

Career Development Statement:

Through clinical and research experiences I have developed a strong interest in psoriasis. After observing the ramifications of psoriasis and its significant effect on patients’ quality of life, I sought out opportunities for exposure including research projects on the metabolomics and epigenetic alterations of psoriatic disease. In leading these projects I have gained invaluable analytical/research skills and learned about the complexities of psoriatic disease. Additionally, I have served on the Dermatology Interest Group Association (DIGA) Psoriasis Committee for over two years and created educational content for patients and medical students. We plan to work with the NPF to disseminate a curriculum on psoriasis to medical students nationally. Through the Summer Student Research Grant, I would be afforded the opportunity to contribute new insights into the metabolomics of psoriasis and develop important skills for a career as an academic dermatologist investigating a cure for psoriasis.

Impact of NPF-Funded Research

The NPF has awarded over $30 million in research funding in recent years, with immeasurable impact on our community.

Read more

We Need Your Help

With your gift we can fund even more research to get better treatment and diagnostic options and someday, a cure.

Help fund critical research

NPF-Funded Research

Discover our other active research projects.

Learn more

Stay in the Know.

Expert tips, can’t-miss events and the latest news, straight to your inbox.

National Health Council Standards of ExcellenceCharity NavigatorCommunity Health Charities logoTwill Care logo

Copyright © 1996-2022 National Psoriasis Foundation/USA

Duplication, rebroadcast, republication or other use of content appearing on this website is prohibited without written permission of the National Psoriasis Foundation (NPF).

NPF does not endorse or accept any responsibility for the content of external websites.

NPF does not endorse any specific treatments or medications for psoriasis and psoriatic arthritis.

We use cookies to offer you a better experience and analyze our site traffic. By continuing to use this website, you consent to the use of cookies in accordance with our Privacy Policy.